Targeted proteomics using stable isotope labeled protein fragments enables precise and robust determination of total apolipoprotein(a) in human plasma

• Andreas Hober,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Science for Life Laboratory, Solna, Sweden, Division of Systems Biology, Department of Protein Science, School of Chemistry, Biotechnology and Health, The Royal Institute of Technology (KTH), Stockholm, Sweden

  https://orcid.org/0000-0001-8947-2562

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• Mirela Rekanovic,

  Roles Formal analysis, Writing – review & editing

  Affiliation Translational Science and Experimental Medicine, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

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• Björn Forsström,

  Roles Conceptualization, Data curation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Science for Life Laboratory, Solna, Sweden, Division of Systems Biology, Department of Protein Science, School of Chemistry, Biotechnology and Health, The Royal Institute of Technology (KTH), Stockholm, Sweden

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• Sara Hansson,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliation Translational Science and Experimental Medicine, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

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• David Kotol,

  Roles Formal analysis, Writing – review & editing

  Affiliations Science for Life Laboratory, Solna, Sweden, Division of Systems Biology, Department of Protein Science, School of Chemistry, Biotechnology and Health, The Royal Institute of Technology (KTH), Stockholm, Sweden

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• Andrew J. Percy,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Applications Development, Cambridge Isotope Laboratories, Inc., Tewksbury, Massachusetts, United States of America

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• Mathias Uhlén,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Science for Life Laboratory, Solna, Sweden, Division of Systems Biology, Department of Protein Science, School of Chemistry, Biotechnology and Health, The Royal Institute of Technology (KTH), Stockholm, Sweden

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• Jan Oscarsson,

  Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Late-stage Development, Cardiovascular, Renal and Metabolism, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Fredrik Edfors ,

  Contributed equally to this work with: Fredrik Edfors, Tasso Miliotis

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Science for Life Laboratory, Solna, Sweden, Division of Systems Biology, Department of Protein Science, School of Chemistry, Biotechnology and Health, The Royal Institute of Technology (KTH), Stockholm, Sweden

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• Tasso Miliotis

  Contributed equally to this work with: Fredrik Edfors, Tasso Miliotis

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: tasso.miliotis@astrazeneca.com

  Affiliation Translational Science and Experimental Medicine, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

  https://orcid.org/0000-0003-4917-0724

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