Higher Dose Oral Fluconazole for the Treatment of AIDS-related Cryptococcal Meningitis (HIFLAC)—report of A5225, a multicentre, phase I/II, two-stage, dose-finding, safety, tolerability and efficacy randomised, amphotericin B-controlled trial of the AIDS Clinical Trials Group

• Umesh G. Lalloo ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: umeshlalloo@gmail.com

  Affiliation Durban University of Technology, Durban, South Africa

  https://orcid.org/0000-0002-5950-3118

  ⨯
• Lauren Komarow ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation Harvard TH Chan School of Public Health, Boston, Massachusetts, and The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America

  ⨯
• Judith A. Aberg ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0001-8162-0284

  ⨯
• David B. Clifford ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Washington University School of Medicine, St Louis, Missouri, United States of America

  ⨯
• Evelyn Hogg ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Visualization, Writing – review & editing

  Affiliation Social & Scientific Systems, Inc., a DLH Holdings Company, Silver Spring, Maryland, United States of America

  ⨯
• Ashley McKhann ,

  Contributed equally to this work with: Umesh G. Lalloo, Lauren Komarow, Judith A. Aberg, David B. Clifford, Evelyn Hogg, Ashley McKhann

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation Harvard TH Chan School of Public Health, Boston, Massachusetts, and The Biostatistics Center, The George Washington University, Rockville, Maryland, United States of America

  ⨯
• Aggrey Bukuru ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation Joint Clinical Research Centre, Kampala, Uganda

  ⨯
• David Lagat ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation MOI University Teaching Hospital, Eldoret, Kenya

  ⨯
• Sandy Pillay ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation Durban University of Technology, Durban, South Africa

  ⨯
• Vidya Mave ,

  Roles Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation BJ Medical School, Pune, Maharashtra, India

  ⨯
• Khuanchai Supparatpinyo ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation Research Institute for Health Sciences, Chang Mai, Thailand

  ⨯
• Wadzanai Samaneka ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation University of Zimbabwe, Harare, Zimbabwe

  ⨯
• Deborah Langat ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation KEMRI Walter Reed Project, Kericho, Kenya

  ⨯
• Eduardo Ticona ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation Hospital Nacional Dos de Mayo, Lima, Peru

  ⨯
• Sharlaa Badal-Faesen ,

  Roles Investigation, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation University of Witwatersrand, Johannesburg, South Africa

  ⨯
• Robert A. Larsen ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – review & editing

  ¶‡ AB, DL, SP, VM, KS, WS, DL, ET, SBF and RAL also contributed equally to this work.

  Affiliation University of Southern California, Los Angeles, California, United States of America

  ⨯
•  [ ... ],
• the ACTG A5225 Team

  ¶Membership of the ACTG A5225 Team is provided in the Acknowledgments.

  ⨯
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