Pretreatment with antibiotics is associated with reduced therapeutic response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma

• Kazuki Maesaka,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Ryotaro Sakamori,

  Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Ryoko Yamada,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Akira Doi,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Yuki Tahata,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Kazuyoshi Ohkawa,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Osaka, Japan

  ⨯
• Masahide Oshita,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Ikeda Municipal Hospital, Ikeda, Osaka, Japan

  ⨯
• Masanori Miyazaki,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka Police Hospital, Osaka, Osaka, Japan

  ⨯
• Takayuki Yakushijin,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Osaka, Japan

  ⨯
• Yasutoshi Nozaki,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan

  ⨯
• Kengo Matsumoto,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Osaka, Japan

  ⨯
• Satoshi Tanaka,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Osaka, Japan

  ⨯
• Akira Kaneko,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Osaka, Japan

  ⨯
• Sadaharu Iio,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan

  ⨯
• Takatoshi Nawa,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Higashiosaka City Medical Center, Higashiosaka, Osaka, Japan

  ⨯
• Yukinori Yamada,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Kaizuka City Hospital, Kaizuka, Osaka, Japan

  ⨯
• Naoki Morishita,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Minoh City Hospital, Minoh, Osaka, Japan

  ⨯
• Takeo Usui,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Ashiya Municipal Hospital, Ashiya, Hyogo, Japan

  ⨯
• Naoki Hiramatsu,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Osaka, Japan

  ⨯
• Yoshinori Doi,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Otemae Hospital, Osaka, Osaka, Japan

  ⨯
• Mitsuru Sakakibara,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Yao Municipal Hospital, Yao, Osaka, Japan

  ⨯
• Kazuho Imanaka,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Itami City Hospital, Itami, Hyogo, Japan

  ⨯
• Yuichi Yoshida,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Suita, Osaka, Japan

  ⨯
• Takahiro Kodama,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Hayato Hikita,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
• Tomohide Tatsumi,

  Roles Writing – review & editing

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  ⨯
•  [ ... ],
• Tetsuo Takehara

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: takehara@gh.med.osaka-u.ac.jp

  Affiliation Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  https://orcid.org/0000-0001-5036-3457

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