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Open Access
Peer-reviewed
Research Article
A machine learning approach identifies distinct early-symptom cluster phenotypes which correlate with hospitalization, failure to return to activities, and prolonged COVID-19 symptoms
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Nusrat J. Epsi,
Roles Data curation, Investigation, Methodology, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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John H. Powers,
Roles Supervision
Affiliation Clinical Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
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David A. Lindholm,
Roles Supervision
Affiliations Molecular Biology Laboratory, Brooke Army Medical Center, San Antonio, Texas, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Katrin Mende,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America, Molecular Biology Laboratory, Brooke Army Medical Center, San Antonio, Texas, United States of America
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Allison Malloy,
Roles Resources
Affiliation Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America
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Anuradha Ganesan,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America, Infectious Disease Clinic, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America
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Nikhil Huprikar,
Roles Resources
Affiliation Infectious Disease Clinic, Walter Reed National Military Medical Center, Bethesda, Maryland, United States of America
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Tahaniyat Lalani,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America, Infectious Disease Clinical Research Program, Naval Medical Center Portsmouth, Portsmouth, Virginia, United States of America
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Alfred Smith,
Roles Resources
Affiliation Infectious Disease Clinical Research Program, Naval Medical Center Portsmouth, Portsmouth, Virginia, United States of America
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Rupal M. Mody,
Roles Resources
Affiliation Infectious Disease Clinic, William Beaumont Army Medical Center, El Paso, Texas, United States of America
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Milissa U. Jones,
Roles Resources
Affiliation Pediatric Infectious Diseases, Tripler Army Medical Center, Honolulu, Hawaii, United States of America
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Samantha E. Bazan,
Roles Resources
Affiliation Family Nurse Practitioner and Women’s Health Nurse Practitioner Program, Carl R. Darnall Army Medical Center, Fort Hood, Texas, United States of America
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Rhonda E. Colombo,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Disease Clinic, Madigan Army Medical Center, Tacoma, Washington, United States of America
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Christopher J. Colombo,
Roles Resources
Affiliation Infectious Disease Clinic, Madigan Army Medical Center, Tacoma, Washington, United States of America
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Evan C. Ewers,
Roles Resources
Affiliation Internal Medicine, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, United States of America
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Derek T. Larson,
Roles Resources
Affiliations Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Internal Medicine, Fort Belvoir Community Hospital, Fort Belvoir, Virginia, United States of America, Infectious Disease Clinic, Naval Medical Center San Diego, San Diego, California, United States of America
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Catherine M. Berjohn,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Disease Clinic, Naval Medical Center San Diego, San Diego, California, United States of America
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Carlos J. Maldonado,
Roles Resources
Affiliation Department of Research and Clinical Investigation, Womack Army Medical Center, Fort Bragg, North Carolina, United States of America
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Paul W. Blair,
Roles Resources
Affiliations Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Josh Chenoweth,
Roles Resources
Affiliation Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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David L. Saunders,
Roles Resources
Affiliation Translational Medicine Unit, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Jeffrey Livezey,
Roles Resources
Affiliation Translational Medicine Unit, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Ryan C. Maves,
Roles Resources
Affiliation Infectious Diseases and Critical Care Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America
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Margaret Sanchez Edwards,
Roles Resources
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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Julia S. Rozman,
Roles Project administration
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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Mark P. Simons,
Roles Funding acquisition, Project administration, Supervision
Affiliation Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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David R. Tribble,
Roles Funding acquisition, Project administration
Affiliation Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Brian K. Agan,
Roles Funding acquisition, Project administration
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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Timothy H. Burgess,
Roles Funding acquisition, Project administration
Affiliation Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
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Simon D. Pollett,
Roles Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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for the EPICC COVID-19 Cohort Study Group
* E-mail: srichard@idcrp.org
¶Membership of the EPICC COVID-19 Cohort Study Group is provided in the Acknowledgments.
Affiliations Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America
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A machine learning approach identifies distinct early-symptom cluster phenotypes which correlate with hospitalization, failure to return to activities, and prolonged COVID-19 symptoms
- Nusrat J. Epsi,
- John H. Powers,
- David A. Lindholm,
- Katrin Mende,
- Allison Malloy,
- Anuradha Ganesan,
- Nikhil Huprikar,
- Tahaniyat Lalani,
- Alfred Smith,
- Rupal M. Mody
- Published: February 9, 2023
- https://doi.org/10.1371/journal.pone.0281272