HIV-1 release requires Nef-induced caspase activation

Jason Segura; Joanna Ireland; Zhongcheng Zou; Gwynne Roth; Julianna Buchwald; Thomas J. Shen; Elizabeth Fischer; Susan Moir; Tae-Wook Chun; Peter D. Sun

doi:10.1371/journal.pone.0281087

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Open Access

Peer-reviewed

Research Article

HIV-1 release requires Nef-induced caspase activation

Jason Segura,

Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Joanna Ireland,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Zhongcheng Zou,

Roles Data curation, Formal analysis

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Gwynne Roth,

Roles Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Julianna Buchwald,

Roles Data curation, Formal analysis

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Thomas J. Shen,

Roles Data curation, Formal analysis

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Elizabeth Fischer,

Roles Data curation, Formal analysis

Affiliation Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Susan Moir,

Roles Methodology, Resources

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Tae-Wook Chun,

Roles Data curation, Formal analysis, Methodology

Affiliation Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Peter D. Sun

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: psun@nih.gov

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

https://orcid.org/0000-0003-0475-1891

⨯

HIV-1 release requires Nef-induced caspase activation

Jason Segura,
Joanna Ireland,
Zhongcheng Zou,
Gwynne Roth,
Julianna Buchwald,
Thomas J. Shen,
Elizabeth Fischer,
Susan Moir,
Tae-Wook Chun,
Peter D. Sun

Published: February 13, 2023
https://doi.org/10.1371/journal.pone.0281087

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HIV-1
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HIV
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T helper cells
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Viral release
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Apoptosis
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HIV infections
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Virions
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Viral transmission and infection
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