Modeling in higher dimensions to improve diagnostic testing accuracy: Theory and examples for multiplex saliva-based SARS-CoV-2 antibody assays

• Rayanne A. Luke ,

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rluke3@jhu.edu

  Affiliations Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, United States of America, Applied and Computational Mathematics Division, National Institute of Standards and Technology, Gaithersburg, MD, United States of America

  https://orcid.org/0000-0002-1636-8438

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• Anthony J. Kearsley,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Applied and Computational Mathematics Division, National Institute of Standards and Technology, Gaithersburg, MD, United States of America

  https://orcid.org/0000-0002-9576-0621

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• Nora Pisanic,

  Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, United States of America

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• Yukari C. Manabe,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America

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• David L. Thomas,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America

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• Christopher D. Heaney ,

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Writing – review & editing

  ¶‡ CDH and PNP are senior authors on this work.

  Affiliations Department of Environmental Health and Engineering, Johns Hopkins University, Baltimore, MD, United States of America, Department of Internal Health, Johns Hopkins University, Baltimore, MD, United States of America, Department of Epidemiology, Johns Hopkins University, Baltimore, MD, United States of America

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• Paul N. Patrone

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ CDH and PNP are senior authors on this work.

  Affiliation Applied and Computational Mathematics Division, National Institute of Standards and Technology, Gaithersburg, MD, United States of America

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