Toxicity of tributyltin to the European flat oyster Ostrea edulis: Metabolomic responses indicate impacts to energy metabolism, biochemical composition and reproductive maturation

• Lina M. Zapata-Restrepo ,

  Contributed equally to this work with: Lina M. Zapata-Restrepo, David Hauton

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: lmzr1f20@soton.ac.uk

  ¶☯ These authors contributed equally to this work.

  Affiliation School of Geography and Environmental Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom

  https://orcid.org/0000-0003-2549-6711

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• Chris Hauton,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Ocean and Earth Sciences, National Oceanography Centre, University of Southampton, Southampton, Hampshire, United Kingdom

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• Malcolm D. Hudson,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation School of Geography and Environmental Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom

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• Ian D. Williams,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Faculty of Engineering and Physical Sciences, University of Southampton, Highfield Campus, Southampton, United Kingdom

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• David Hauton

  Contributed equally to this work with: Lina M. Zapata-Restrepo, David Hauton

  Roles Formal analysis, Methodology, Resources, Validation, Visualization, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliation Metabolomics Research Group, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom

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