Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel

• Mengyan Wei ,

  Contributed equally to this work with: Mengyan Wei, Pu Wang, Xiufang Zhu

  Roles Data curation, Investigation

  Affiliations Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China, Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Pu Wang ,

  Contributed equally to this work with: Mengyan Wei, Pu Wang, Xiufang Zhu

  Roles Data curation

  Affiliations Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China, Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Xiufang Zhu ,

  Contributed equally to this work with: Mengyan Wei, Pu Wang, Xiufang Zhu

  Roles Data curation

  Affiliations Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China, Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Masaki Morishima,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Food Science and Nutrition, Faculty of Agriculture, Kindai University, Nara, Japan

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• Yangong Liu,

  Roles Data curation

  Affiliations Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China, Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Mingqi Zheng,

  Roles Formal analysis, Methodology

  Affiliation Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China

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• Gang Liu,

  Roles Methodology, Project administration

  Affiliation Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People’s Republic of China

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• Hiroki Osanai,

  Roles Formal analysis

  Affiliation Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Kenshi Yoshimura,

  Roles Investigation

  Affiliation Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Shinichiro Kume,

  Roles Formal analysis

  Affiliation Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Tatsuki Kurokawa,

  Roles Formal analysis

  Affiliation Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

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• Katsushige Ono

  Roles Supervision, Writing – original draft

  * E-mail: ono@oita-u.ac.jp

  Affiliation Department of Pathophysiology, Oita University School of Medicine, Yufu, Oita, Japan

  https://orcid.org/0000-0001-7949-1823

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