Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels

• Manae Tatsumi,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Takayuki Kishi,

  Roles Investigation

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Satoru Ishida,

  Roles Investigation

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Hiroki Kawana,

  Roles Investigation

  Affiliation Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

  https://orcid.org/0000-0002-9695-5973

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• Akiharu Uwamizu,

  Roles Investigation

  Affiliation Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Yuki Ono,

  Roles Investigation

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Kouki Kawakami,

  Roles Investigation

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

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• Junken Aoki,

  Roles Funding acquisition, Supervision

  Affiliation Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

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• Asuka Inoue

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: iaska@tohoku.ac.jp

  Affiliation Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

  https://orcid.org/0000-0003-0805-4049

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