Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues

• Arvin H. Soepriatna ,

  Contributed equally to this work with: Arvin H. Soepriatna, Allison Navarrete-Welton

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-7756-1389

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• Allison Navarrete-Welton ,

  Contributed equally to this work with: Arvin H. Soepriatna, Allison Navarrete-Welton

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-3124-5743

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• Tae Yun Kim,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

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• Mark C. Daley,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-7236-5215

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• Peter Bronk,

  Roles Conceptualization, Data curation, Methodology, Software, Validation, Writing – review & editing

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

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• Celinda M. Kofron,

  Roles Conceptualization, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, United States of America

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• Ulrike Mende,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0002-3362-6072

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• Kareen L. K. Coulombe,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Center for Biomedical Engineering, School of Engineering, Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0001-6664-339X

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• Bum-Rak Choi

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Bum-Rak_Choi@brown.edu

  Affiliation Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

  https://orcid.org/0000-0001-7319-3219

  ⨯