High-throughput phenotypic screen identifies a new family of potent anti-amoebic compounds

• Conall Sauvey ,

  Contributed equally to this work with: Conall Sauvey, Ittipat Meewan

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School for Pharmacy and Pharmaceutical Sciences, University of California—San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0002-7160-7163

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• Ittipat Meewan ,

  Contributed equally to this work with: Conall Sauvey, Ittipat Meewan

  Roles Conceptualization, Data curation, Formal analysis, Software, Visualization, Writing – review & editing

  Affiliations Center for Discovery and Innovation in Parasitic Diseases, Skaggs School for Pharmacy and Pharmaceutical Sciences, University of California—San Diego, La Jolla, California, United States of America, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand

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• Gretchen Ehrenkaufer,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Internal Medicine, Stanford University School of Medicine, Stanford, California, United States of America

  https://orcid.org/0000-0002-5009-1399

  ⨯
• Jonathan Blevitt,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Janssen Research and Development, LLC, Ja Jolla, California, United States of America

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• Paul Jackson ,

  Roles Funding acquisition, Resources, Supervision

  ¶‡ PJ and RA also contributed equally to this work.

  Affiliation Janssen Research and Development, LLC, Ja Jolla, California, United States of America

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• Ruben Abagyan

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: rabagyan@health.ucsd.edu

  ¶‡ PJ and RA also contributed equally to this work.

  Affiliation Center for Discovery and Innovation in Parasitic Diseases, Skaggs School for Pharmacy and Pharmaceutical Sciences, University of California—San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0001-9309-2976

  ⨯