A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort

Michael R. Ardern-Jones; Hang T. T. Phan; Florina Borca; Matt Stammers; James Batchelor; Isabel C. Reading; Sophie V. Fletcher; Trevor Smith; Andrew S. Duncombe

doi:10.1371/journal.pone.0280079

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Open Access

Peer-reviewed

Research Article

A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort

Michael R. Ardern-Jones ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: m.aj@soton.ac.uk

Affiliations Clinical Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom, Division of Medicine, University Hospitals Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom

https://orcid.org/0000-0003-1466-2016

⨯
Hang T. T. Phan,

Roles Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliations NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Clinical Informatics Research Unit Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Florina Borca,

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliations NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Clinical Informatics Research Unit Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Matt Stammers,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliations Division of Medicine, University Hospitals Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom, Clinical Informatics Research Unit Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
James Batchelor,

Roles Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

Affiliations NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Clinical Informatics Research Unit Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Isabel C. Reading,

Roles Data curation, Formal analysis, Investigation, Supervision, Visualization, Writing – review & editing

Affiliation Department of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, United Kingdom
⨯
Sophie V. Fletcher,

Roles Data curation, Methodology, Project administration, Writing – review & editing

Affiliations NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, Department of Respiratory Medicine, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯
Trevor Smith,

Roles Formal analysis, Supervision, Visualization, Writing – review & editing

Affiliation Division of Medicine, University Hospitals Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, United Kingdom
⨯
Andrew S. Duncombe

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliation Department of Haematology, University Hospitals Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯

A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort

Michael R. Ardern-Jones,
Hang T. T. Phan,
Florina Borca,
Matt Stammers,
James Batchelor,
Isabel C. Reading,
Sophie V. Fletcher,
Trevor Smith,
Andrew S. Duncombe

Published: January 17, 2023
https://doi.org/10.1371/journal.pone.0280079

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