Cancer stem cell-derived extracellular vesicles preferentially target MHC-II–macrophages and PD1+ T cells in the tumor microenvironment

• Patricia Gonzalez-Callejo,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Bionanoplasmonics Group, CIC biomaGUNE, Donostia-San Sebastián, Spain

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• Zihan Guo,

  Roles Investigation

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Program in Biomedical Sciences, Oregon Health and Science University, Portland, Oregon, United States of America

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• Tahereh Ziglari,

  Roles Investigation

  Affiliation Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Natalie Marcia Claudio,

  Roles Investigation

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America

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• Kayla Hoang Nguyen,

  Roles Investigation

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Program in Biomedical Sciences, Oregon Health and Science University, Portland, Oregon, United States of America

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• Naoki Oshimori,

  Roles Resources, Writing – review & editing

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Program in Biomedical Sciences, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Dermatology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Joaquim Seras-Franzoso,

  Roles Methodology, Writing – original draft

  Affiliation Drug Delivery and Targeting Group, Vall d’Hebron Research Institute (VHIR), Barcelona, Spain

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• Ferdinando Pucci

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: pucci@ohsu.edu

  Affiliations Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Program in Biomedical Sciences, Oregon Health and Science University, Portland, Oregon, United States of America, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America

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