Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model

• Yoshie Gon,

  Roles Formal analysis, Investigation, Project administration, Writing – original draft

  Affiliations Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan

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• Tsugumitsu Kandou,

  Roles Formal analysis, Investigation

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Tatsuaki Tsuruyama,

  Roles Investigation, Supervision

  Affiliation Department of Drug Discovery Medicine, Pathology Division, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Takeshi Iwasaki,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Koji Kitagori,

  Roles Project administration, Writing – review & editing

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Kosaku Murakami,

  Roles Writing – review & editing

  Affiliation Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Ran Nakashima,

  Roles Writing – review & editing

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Shuji Akizuki,

  Roles Writing – review & editing

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Akio Morinobu,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Masaki Hikida,

  Roles Methodology, Supervision

  Affiliation Faculty of Engineering Science, Graduate School of Engineering Science, Akita University, Akita, Japan

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• Tsuneyo Mimori,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliations Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Ijinkai Takeda General Hospital, Kyoto, Japan

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• Hajime Yoshifuji

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

  * E-mail: yossii@kuhp.kyoto-u.ac.jp

  Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

  https://orcid.org/0000-0001-7082-4900

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