Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer

Chandru Gajendran; Subramanyam Janardhan Tantry; Naveen Sadhu M.; Zainuddin Mohammed; Purushottam Dewang; Mahanandeesha Hallur; Sreekala Nair; Krishnakumar Vaithilingam; Basavaprabhu Nagayya; Sridharan Rajagopal; Dhanalakshmi Sivanandhan

doi:10.1371/journal.pone.0279063

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Open Access

Peer-reviewed

Research Article

Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer

Chandru Gajendran ,

Contributed equally to this work with: Chandru Gajendran, Subramanyam Janardhan Tantry, Purushottam Dewang, Sreekala Nair, Sridharan Rajagopal

Roles Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Jubilant Therapeutics India Ltd, Bangalore, India
⨯
Subramanyam Janardhan Tantry ,

Contributed equally to this work with: Chandru Gajendran, Subramanyam Janardhan Tantry, Purushottam Dewang, Sreekala Nair, Sridharan Rajagopal

Roles Formal analysis, Investigation, Project administration, Supervision

Affiliation Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore, India
⨯
Naveen Sadhu M. ,

Roles Conceptualization, Methodology

¶‡ NSM, ZM, MH, KV, and BN also contributed equally to this work.

Affiliation Jubilant Therapeutics India Ltd, Bangalore, India
⨯
Zainuddin Mohammed ,

Roles Formal analysis, Methodology, Supervision

¶‡ NSM, ZM, MH, KV, and BN also contributed equally to this work.

Affiliation Jubilant Therapeutics India Ltd, Bangalore, India
⨯
Purushottam Dewang ,

Contributed equally to this work with: Chandru Gajendran, Subramanyam Janardhan Tantry, Purushottam Dewang, Sreekala Nair, Sridharan Rajagopal

Roles Supervision

Affiliation Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore, India
⨯
Mahanandeesha Hallur ,

Roles Supervision

¶‡ NSM, ZM, MH, KV, and BN also contributed equally to this work.

Affiliation Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore, India
⨯
Sreekala Nair ,

Contributed equally to this work with: Chandru Gajendran, Subramanyam Janardhan Tantry, Purushottam Dewang, Sreekala Nair, Sridharan Rajagopal

Roles Investigation, Methodology, Supervision

Affiliation Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore, India
⨯
Krishnakumar Vaithilingam ,

Roles Methodology, Validation

¶‡ NSM, ZM, MH, KV, and BN also contributed equally to this work.

Affiliation Department of Structural Biology, Jubilant Biosys Ltd, Bangalore, India
⨯
Basavaprabhu Nagayya ,

Roles Methodology

¶‡ NSM, ZM, MH, KV, and BN also contributed equally to this work.

Affiliation Department of Discovery Biology, Jubilant Biosys Ltd, Bangalore, India
⨯
Sridharan Rajagopal ,

Contributed equally to this work with: Chandru Gajendran, Subramanyam Janardhan Tantry, Purushottam Dewang, Sreekala Nair, Sridharan Rajagopal

Roles Conceptualization, Investigation, Supervision, Visualization

Affiliation Jubilant Therapeutics India Ltd, Bangalore, India
⨯
Dhanalakshmi Sivanandhan

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: Dhanalakshmi.Sivanandhan@jubilanttx.com

Affiliation Jubilant Therapeutics India Ltd, Bangalore, India

https://orcid.org/0000-0002-8095-3869

⨯

Novel dual LSD1/HDAC6 inhibitor for the treatment of cancer

Chandru Gajendran,
Subramanyam Janardhan Tantry,
Naveen Sadhu M.,
Zainuddin Mohammed,
Purushottam Dewang,
Mahanandeesha Hallur,
Sreekala Nair,
Krishnakumar Vaithilingam,
Basavaprabhu Nagayya,
Sridharan Rajagopal

Published: January 3, 2023
https://doi.org/10.1371/journal.pone.0279063

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