Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants

Alyssa Kriegermeier; Angela Hyon; Brian LeCuyer; Susan Hubchak; Xiaoying Liu; Richard M. Green

doi:10.1371/journal.pone.0279016

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Peer-reviewed

Research Article

Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants

Alyssa Kriegermeier ,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft

* E-mail: akriegermeier@luriechildrens.org

Affiliation Division of Gastroenterology, Hepatology and Nutrition at Ann & Robert H. Lurie Children’s Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America

https://orcid.org/0000-0003-0143-7450

⨯
Angela Hyon,

Roles Investigation

Affiliation Division of Gastroenterology, Hepatology and Nutrition at Ann & Robert H. Lurie Children’s Hospital of Chicago, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Brian LeCuyer,

Roles Investigation

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Susan Hubchak,

Roles Investigation, Methodology

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Xiaoying Liu,

Roles Methodology, Writing – review & editing

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯
Richard M. Green

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Division of Gastroenterology and Hepatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America
⨯

Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants

Alyssa Kriegermeier,
Angela Hyon,
Brian LeCuyer,
Susan Hubchak,
Xiaoying Liu,
Richard M. Green

Published: December 15, 2022
https://doi.org/10.1371/journal.pone.0279016

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Gene expression
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Endoplasmic reticulum
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Liver transplantation
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Protein expression
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Fibrosis
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