Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase

• Hiroki Iida,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Takashi Onuma,

  Roles Writing – original draft

  Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Daiki Nakashima,

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Daisuke Mizutani,

  Roles Data curation, Investigation, Writing – original draft

  Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

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• Takamitsu Hori,

  Roles Data curation, Investigation

  Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

  https://orcid.org/0000-0002-8673-7868

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• Kyohei Ueda,

  Roles Data curation, Investigation

  Affiliations Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Tomoyuki Hioki,

  Roles Data curation, Investigation

  Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Dermatology, Kizawa Memorial Hospital, Minokamo, Japan

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• Woo Kim,

  Roles Data curation, Investigation

  Affiliations Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Yukiko Enomoto,

  Roles Data curation, Methodology

  Affiliation Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan

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• Tomoaki Doi,

  Roles Methodology

  Affiliation Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Rie Matsushima-Nishiwaki,

  Roles Data curation, Formal analysis, Validation, Visualization

  Affiliation Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Shinobu Yamaguchi,

  Roles Methodology

  Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Junko Tachi,

  Roles Data curation, Investigation

  Affiliations Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

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• Kumiko Tanabe,

  Roles Methodology

  Affiliation Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Shinji Ogura,

  Roles Methodology

  Affiliation Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan

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• Toru Iwama,

  Roles Methodology

  Affiliation Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan

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• Osamu Kozawa ,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: okkasugai@yahoo.co.jp

  Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

  https://orcid.org/0000-0002-4834-6073

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•  [ ... ],
• Haruhiko Tokuda

  Roles Conceptualization, Data curation, Supervision, Validation, Writing – review & editing

  Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Metabolic Research, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, Department of Clinical Laboratory/Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan

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