Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study

David E. Komatsu; Sardar M. Z. Uddin; Chris Gordon; Martha P. Kanjiya; Diane Bogdan; Justice Achonu; Adriana DiBua; Hira Iftikhar; Amanda Ackermann; Rohan J. Shah; Jason Shieh; Agnieszka B. Bialkowska; Martin Kaczocha

doi:10.1371/journal.pone.0278632

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Open Access

Peer-reviewed

Research Article

Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study

David E. Komatsu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: David.Komatsu@stonybrookmedicine.edu (DEK); Martin.Kaczocha@stonybrook.edu (MK)

Affiliation Department of Orthopaedics and Rehabilitation, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Sardar M. Z. Uddin,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Orthopaedics and Rehabilitation, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Chris Gordon,

Roles Data curation, Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Martha P. Kanjiya,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Diane Bogdan,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Justice Achonu,

Roles Investigation

Affiliation Department of Orthopaedics and Rehabilitation, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Adriana DiBua,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America

https://orcid.org/0000-0001-6369-9216

⨯
Hira Iftikhar,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Amanda Ackermann,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Rohan J. Shah,

Roles Investigation

Affiliation Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America

https://orcid.org/0000-0002-6930-0605

⨯
Jason Shieh,

Roles Formal analysis, Visualization

Affiliation Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America
⨯
Agnieszka B. Bialkowska,

Roles Formal analysis, Visualization

Affiliation Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America

https://orcid.org/0000-0003-2127-7714

⨯
Martin Kaczocha

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: David.Komatsu@stonybrookmedicine.edu (DEK); Martin.Kaczocha@stonybrook.edu (MK)

Affiliations Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook University Pain and Analgesia Research Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States of America

https://orcid.org/0000-0002-2527-1398

⨯

Acute postoperative pain and dorsal root ganglia transcriptomic signatures following total knee arthroplasty (TKA) in rats: An experimental study

David E. Komatsu,
Sardar M. Z. Uddin,
Chris Gordon,
Martha P. Kanjiya,
Diane Bogdan,
Justice Achonu,
Adriana DiBua,
Hira Iftikhar,
Amanda Ackermann,
Rohan J. Shah

Published: December 6, 2022
https://doi.org/10.1371/journal.pone.0278632

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Pain
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Surgical and invasive medical procedures
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Total knee arthroplasty
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Prosthetics
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Gait analysis
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