The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation

Lynda Bourebaba; Sai Santosh Babu Komakula; Christine Weiss; Nabil Adrar; Krzysztof Marycz

doi:10.1371/journal.pone.0278566

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Peer-reviewed

Research Article

The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation

Lynda Bourebaba,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland, International Institute of Translational Medicine, Jesionowa, Wisznia Mała, Poland

https://orcid.org/0000-0003-0660-8706

⨯
Sai Santosh Babu Komakula,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland

https://orcid.org/0000-0001-6109-2736

⨯
Christine Weiss,

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland, PferdePraxis Dr. Med. Vet. Daniel Weiss, Freienbach, Switzerland
⨯
Nabil Adrar,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland

https://orcid.org/0000-0003-3723-3003

⨯
Krzysztof Marycz

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Validation, Writing – original draft

* E-mail: kmmarycz@ucdavis.edu

Affiliations Faculty of Biology and Animal Science, Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland, International Institute of Translational Medicine, Jesionowa, Wisznia Mała, Poland, Department of Medicine and Epidemiology, UC Davis School of Veterinary Medicine, Davis, CA, United States of America
⨯

The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulation

Lynda Bourebaba,
Sai Santosh Babu Komakula,
Christine Weiss,
Nabil Adrar,
Krzysztof Marycz

Published: January 17, 2023
https://doi.org/10.1371/journal.pone.0278566

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Endoplasmic reticulum
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Mitochondria
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Apoptosis
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Hepatocytes
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Gene expression
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Stress signaling cascade
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Insulin resistance
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