Dihydroxyacetone suppresses mTOR nutrient signaling and induces mitochondrial stress in liver cells

• Arlet Hernandez ,

  Contributed equally to this work with: Arlet Hernandez, Manoj Sonavane

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham AL, United States of America

  ⨯
• Manoj Sonavane ,

  Contributed equally to this work with: Arlet Hernandez, Manoj Sonavane

  Roles Data curation, Formal analysis, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham AL, United States of America

  ⨯
• Kelly R. Smith,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States of America

  ⨯
• Jensyn Seiger,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States of America

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• Marie E. Migaud,

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States of America, Department of Pharmacology, University of South Alabama Whiddon College of Medicine, Mobile, AL, United States of America

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• Natalie R. Gassman

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: nrg2@uab.edu

  Affiliation Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham AL, United States of America

  https://orcid.org/0000-0002-8488-2332

  ⨯