Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

Bo Wu; Morgan Drains; Sapana N. Shah; Pei Juan Lu; Victoria Leroy; Jessalyn Killilee; Raegan Rawls; Jason D. Tucker; Anthony Blaeser; Qi Long Lu

doi:10.1371/journal.pone.0278482

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Open Access

Peer-reviewed

Research Article

Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

Bo Wu ,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft

* E-mail: Bo.Wu@atriumhealth.org (BW); Qi.Lu@atriumhealth.org (QLL)

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Morgan Drains,

Roles Investigation, Methodology, Validation, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Sapana N. Shah,

Roles Investigation, Methodology, Project administration, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Pei Juan Lu,

Roles Investigation, Methodology, Validation, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Victoria Leroy,

Roles Investigation, Methodology, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Jessalyn Killilee,

Roles Investigation, Validation, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Raegan Rawls,

Roles Investigation, Methodology, Validation, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America

https://orcid.org/0000-0001-8516-9590

⨯
Jason D. Tucker,

Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America

https://orcid.org/0000-0001-6558-7808

⨯
Anthony Blaeser,

Roles Investigation, Methodology, Supervision, Validation, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Qi Long Lu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: Bo.Wu@atriumhealth.org (BW); Qi.Lu@atriumhealth.org (QLL)

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America

https://orcid.org/0000-0002-6969-0121

⨯

Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

Bo Wu,
Morgan Drains,
Sapana N. Shah,
Pei Juan Lu,
Victoria Leroy,
Jessalyn Killilee,
Raegan Rawls,
Jason D. Tucker,
Anthony Blaeser,
Qi Long Lu

Published: December 1, 2022
https://doi.org/10.1371/journal.pone.0278482

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