Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

• Philipp Jordan ,

  Contributed equally to this work with: Philipp Jordan, Amanda Costa

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany

  ⨯
• Amanda Costa ,

  Contributed equally to this work with: Philipp Jordan, Amanda Costa

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany, Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States of America

  ⨯
• Edgar Specker,

  Roles Conceptualization, Formal analysis

  Affiliations Screening Unit, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany, Medicinal Chemistry Research Group, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany

  ⨯
• Oliver Popp,

  Roles Formal analysis

  Affiliation Max-Delbrück-Center for Molecular Medicine, Mass spectroscopy and Proteomics, Berlin, Germany

  ⨯
• Andrea Volkamer,

  Roles Data curation, Formal analysis

  Affiliation Dept. of Physiology, In Silico Toxicology and Structural Bioinformatics, Charité-Universitätsmedizin Berlin, Berlin, Germany

  ⨯
• Regina Piske,

  Roles Data curation, Methodology

  Affiliation Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany

  ⨯
• Tessa Obrusnik,

  Roles Data curation, Formal analysis

  Affiliation Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany

  ⨯
• Sabrina Kleissle,

  Roles Data curation, Methodology

  Affiliations Screening Unit, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, RNAi Platform, Berlin, Germany

  ⨯
• Kevin Stuke,

  Roles Methodology

  Affiliation Medicinal Chemistry Research Group, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany

  ⨯
• Andre Rex,

  Roles Data curation, Methodology

  Affiliation Centre for Stroke Research, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

  https://orcid.org/0000-0003-3924-956X

  ⨯
• Martin Neuenschwander,

  Roles Formal analysis, Methodology

  Affiliation Screening Unit, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany

  ⨯
• Jens Peter von Kries,

  Roles Supervision

  Affiliation Screening Unit, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany

  ⨯
• Marc Nazare,

  Roles Supervision

  Affiliation Medicinal Chemistry Research Group, Leibniz Research Institute for Molecular Pharmacology FMP, Berlin, Germany

  ⨯
• Phillip Mertins,

  Roles Supervision

  Affiliation Max-Delbrück-Center for Molecular Medicine, Mass spectroscopy and Proteomics, Berlin, Germany

  ⨯
• Helmut Kettenmann,

  Roles Conceptualization, Funding acquisition, Writing – original draft

  Affiliations Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

  ⨯
•  [ ... ],
• Susanne A. Wolf

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: Susanne.wolf@charite.de

  Affiliations Max-Delbrück-Center for Molecular Medicine, Cellular Neuroscience, Berlin, Germany, Dept. Ophthalmology, Charité-Universitätsmedizin Berlin, Berlin, Germany

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