The pharmacokinetics and pharmacodynamics of cefquinome against Streptococcus agalactiae in a murine mastitis model

Qingwen Yang; Chenghuan Zhang; Xuesong Liu; Longfei Zhang; Kang Yong; Qian Lv; Yi Zhang; Liang Chen; Peng Zhong; Yun Liu

doi:10.1371/journal.pone.0278306

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Open Access

Peer-reviewed

Research Article

The pharmacokinetics and pharmacodynamics of cefquinome against Streptococcus agalactiae in a murine mastitis model

Qingwen Yang,

Roles Investigation, Methodology, Writing – original draft

Affiliation Laboratory of Veterinary Pharmacology, Department of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing, China
⨯
Chenghuan Zhang,

Roles Investigation, Methodology

Affiliation Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
⨯
Xuesong Liu,

Roles Investigation, Methodology, Software

Affiliations Laboratory of Veterinary Pharmacology, Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar, China, Heilongjiang Key Laboratory of Veterinary Medicine, Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar, China
⨯
Longfei Zhang,

Roles Methodology

Affiliation College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China
⨯
Kang Yong,

Roles Formal analysis

Affiliation Laboratory of Veterinary Pharmacology, Department of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing, China
⨯
Qian Lv,

Roles Formal analysis

Affiliation Laboratory of Veterinary Pharmacology, Department of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing, China
⨯
Yi Zhang,

Roles Formal analysis

Affiliation Laboratory of Veterinary Pharmacology, Department of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing, China
⨯
Liang Chen,

Roles Resources

Affiliation Laboratory of Veterinary Pharmacology, Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar, China
⨯
Peng Zhong,

Roles Resources

Affiliations Laboratory of Veterinary Pharmacology, Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar, China, Heilongjiang Key Laboratory of Veterinary Medicine, Branch of Animal Husbandry and Veterinary of Heilongjiang Academy of Agricultural Sciences, Qiqihar, China
⨯
Yun Liu

Roles Conceptualization, Resources, Writing – review & editing

* E-mail: liuyun@neau.edu.cn

Affiliation Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Department of Veterinary Surgery, College of Veterinary Medicine, Northeast Agricultural University, Harbin, China

https://orcid.org/0000-0002-4989-5525

⨯

The pharmacokinetics and pharmacodynamics of cefquinome against Streptococcus agalactiae in a murine mastitis model

Qingwen Yang,
Chenghuan Zhang,
Xuesong Liu,
Longfei Zhang,
Kang Yong,
Qian Lv,
Yi Zhang,
Liang Chen,
Peng Zhong,
Yun Liu

Published: January 25, 2023
https://doi.org/10.1371/journal.pone.0278306

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Streptococcus agalactiae
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Antibacterials
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Mastitis
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Blood plasma
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Mouse models
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Bovine mastitis
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Milk
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Elimination half-life calculation
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