Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

• Stuart Meier,

  Roles Conceptualization, Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Current address: Lung Infection and Immunity Unit, Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa

  ⨯
• James A. Seddon,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliations South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa, Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa, Department of Infectious Diseases, Imperial College London, London, United Kingdom

  ⨯
• Elizna Maasdorp,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa, Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa

  ⨯
• Léanie Kleynhans,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  ⨯
• Nelita du Plessis,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  ⨯
• Andre G. Loxton,

  Roles Investigation, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  ⨯
• Stephanus T. Malherbe,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  ⨯
• Daniel E. Zak,

  Roles Data curation, Writing – review & editing

  Affiliation Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Ethan Thompson,

  Roles Data curation, Writing – review & editing

  Affiliation Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Fergal J. Duffy,

  Roles Writing – review & editing

  Affiliation Seattle Children’s Research Institute, Center for Global Infectious Disease Research, Seattle, WA, United States of America

  ⨯
• Stefan H. E. Kaufmann,

  Roles Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliations Max Planck Institute for Infection Biology, Berlin, Germany, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, Hagler Institute for Advanced Study, Texas A&M University, College Station, TX, United States of America

  ⨯
• Tom H. M. Ottenhoff,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliation Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Thomas J. Scriba,

  Roles Investigation, Writing – review & editing

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  ⨯
• Sara Suliman,

  Roles Writing – review & editing

  Current address: Department of Experimental Medicine, University of San Francisco, San Francisco, United States of America

  Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

  https://orcid.org/0000-0002-5154-576X

  ⨯
• Jayne S. Sutherland,

  Roles Investigation, Project administration, Writing – review & editing

  Affiliation Vaccines & Immunity Theme, Medical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia

  ⨯
• Jill Winter,

  Roles Funding acquisition, Investigation, Project administration, Writing – review & editing

  Affiliation Catalysis Foundation for Health, San Ramon, CA, United States of America

  ⨯
• Helena Kuivaniemi,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa

  https://orcid.org/0000-0001-5753-8766

  ⨯
• Gerhard Walzl,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa

  ⨯
• Gerard Tromp ,

  Roles Conceptualization, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gctromp@sun.ac.za

  Affiliations Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Stellenbosch University, Cape Town, South Africa, DSI–NRF Centre of Excellence for Biomedical Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa, South African Tuberculosis Bioinformatics Initiative, Stellenbosch University, Cape Town, South Africa, Centre for Bioinformatics and Computational Biology, Stellenbosch University, Cape Town, South Africa

  https://orcid.org/0000-0002-7761-0806

  ⨯
• GC6-74 Consortium ,

  ¶Complete membership full author group can be found in the Acknowledgments.

  ⨯
•  [ ... ],
• Catalysis TB Biomarkers Consortium

  ¶Complete membership full author group can be found in the Acknowledgments.

  ⨯
• [ view all ]
• [ view less ]