Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models

Karlijne W. Geijtenbeek; Jolien Janzen; Aleksandra E. Bury; Alicia Sanz-Sanz; Ron A. Hoebe; Marie K. Bondulich; Gillian P. Bates; Eric A. J. Reits; Sabine Schipper-Krom

doi:10.1371/journal.pone.0278130

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Open Access

Peer-reviewed

Research Article

Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models

Karlijne W. Geijtenbeek,

Roles Investigation, Writing – original draft

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands

https://orcid.org/0000-0002-2828-3378

⨯
Jolien Janzen,

Roles Investigation

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯
Aleksandra E. Bury,

Roles Investigation

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯
Alicia Sanz-Sanz,

Roles Investigation

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯
Ron A. Hoebe,

Roles Software

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯
Marie K. Bondulich,

Roles Resources

Affiliation Department of Neurodegenerative Disease, Huntington’s Disease Centre and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, UCL, London, United Kingdom
⨯
Gillian P. Bates,

Roles Resources, Writing – review & editing

Affiliation Department of Neurodegenerative Disease, Huntington’s Disease Centre and UK Dementia Research Institute at UCL, Queen Square Institute of Neurology, UCL, London, United Kingdom
⨯
Eric A. J. Reits ,

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: e.a.reits@amsterdamumc.nl

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯
Sabine Schipper-Krom

Roles Investigation, Supervision, Writing – review & editing

Affiliation Amsterdam UMC Location University of Amsterdam, Medical Biology, Amsterdam, The Netherlands
⨯

Reduction in PA28αβ activation in HD mouse brain correlates to increased mHTT aggregation in cell models

Karlijne W. Geijtenbeek,
Jolien Janzen,
Aleksandra E. Bury,
Alicia Sanz-Sanz,
Ron A. Hoebe,
Marie K. Bondulich,
Gillian P. Bates,
Eric A. J. Reits,
Sabine Schipper-Krom

Published: December 27, 2022
https://doi.org/10.1371/journal.pone.0278130

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