Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells

Hiroaki Shimizu; Yasuhiro Horibata; Izuki Amano; Megan J. Ritter; Mariko Domae; Hiromi Ando; Hiroyuki Sugimoto; Ronald N. Cohen; Anthony N. Hollenberg

doi:10.1371/journal.pone.0277830

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Open Access

Peer-reviewed

Research Article

Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells

Hiroaki Shimizu ,

Roles Conceptualization, Data curation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

* E-mail: shimizuh@dokkyomed.ac.jp

Affiliation Department of Biochemistry, Dokkyo Medical University School of Medicine, Shimotsuga-gun, Tochigi, Japan

https://orcid.org/0000-0003-3903-2854

⨯
Yasuhiro Horibata,

Roles Data curation, Methodology

Affiliation Department of Biochemistry, Dokkyo Medical University School of Medicine, Shimotsuga-gun, Tochigi, Japan
⨯
Izuki Amano,

Roles Data curation, Methodology

Affiliations Department of Integrative Physiology, Graduate School of Medicine, Gunma University, Showa, Maebashi, Gunma, Japan, Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America
⨯
Megan J. Ritter,

Roles Data curation, Methodology

Affiliation Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America
⨯
Mariko Domae,

Roles Data curation

Affiliation Center for Research Collaboration and Support, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University School of Medicine, Shimotsuga-gun, Tochigi, Japan
⨯
Hiromi Ando,

Roles Data curation

Affiliation Department of Biochemistry, Dokkyo Medical University School of Medicine, Shimotsuga-gun, Tochigi, Japan
⨯
Hiroyuki Sugimoto,

Roles Conceptualization, Data curation, Methodology, Supervision, Validation

Affiliation Department of Biochemistry, Dokkyo Medical University School of Medicine, Shimotsuga-gun, Tochigi, Japan
⨯
Ronald N. Cohen,

Roles Conceptualization, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago Medicine, Chicago, IL, United States of America
⨯
Anthony N. Hollenberg

Roles Conceptualization, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Weill Cornell Medical College, New York, NY, United States of America
⨯

Nuclear corepressor SMRT acts as a strong regulator of both β-oxidation and suppressor of fibrosis in the differentiation process of mouse skeletal muscle cells

Hiroaki Shimizu,
Yasuhiro Horibata,
Izuki Amano,
Megan J. Ritter,
Mariko Domae,
Hiromi Ando,
Hiroyuki Sugimoto,
Ronald N. Cohen,
Anthony N. Hollenberg

Published: December 1, 2022
https://doi.org/10.1371/journal.pone.0277830

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Skeletal muscles
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Protein expression
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Cell differentiation
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Muscle differentiation
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Fibrosis
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Gene expression
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Immunohistochemistry techniques
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SMAD signaling
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