Wnt10b protects cardiomyocytes against doxorubicin-induced cell death via MAPK modulation

Lei Chen; Stefano H. Byer; Rachel Holder; Lingyuan Wu; Kyley Burkey; Zubair Shah

doi:10.1371/journal.pone.0277747

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Open Access

Peer-reviewed

Research Article

Wnt10b protects cardiomyocytes against doxorubicin-induced cell death via MAPK modulation

Lei Chen ,

Roles Formal analysis, Methodology, Software, Validation, Visualization

¶‡ LC and SHB are co-first authors.

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America
⨯
Stefano H. Byer ,

Roles Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

¶‡ LC and SHB are co-first authors.

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America

https://orcid.org/0000-0003-2828-1943

⨯
Rachel Holder,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America

https://orcid.org/0000-0001-5684-4761

⨯
Lingyuan Wu,

Roles Methodology

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America

https://orcid.org/0000-0002-8548-6526

⨯
Kyley Burkey,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America
⨯
Zubair Shah

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: zshah2@kumc.edu

Affiliation Department of Cardiovascular Medicine, University of Kansas School of Medicine, Kansas City, KS, United States of America

https://orcid.org/0000-0002-3221-3655

⨯

Wnt10b protects cardiomyocytes against doxorubicin-induced cell death via MAPK modulation

Lei Chen,
Stefano H. Byer,
Rachel Holder,
Lingyuan Wu,
Kyley Burkey,
Zubair Shah

Published: October 19, 2023
https://doi.org/10.1371/journal.pone.0277747

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MAPK signaling cascades
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Apoptosis
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Mitochondria
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Cardiomyocytes
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Mitochondrial membrane
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Cell membranes
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Cytotoxicity assay
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Membrane potential
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