Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase

• Heung-Bok Kim ,

  Contributed equally to this work with: Heung-Bok Kim, John-Paul Bacik

  Roles Investigation, Writing – original draft

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  ⨯
• John-Paul Bacik ,

  Contributed equally to this work with: Heung-Bok Kim, John-Paul Bacik

  Roles Investigation, Writing – review & editing

  Affiliations Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, Hauptman-Woodward Medical Research Institute, Buffalo, New York, United States of America

  ⨯
• Ruilian Wu,

  Roles Resources

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  ⨯
• Ramesh K. Jha,

  Roles Investigation, Writing – review & editing

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0001-5904-3441

  ⨯
• Michaeline Hebron,

  Roles Investigation

  Affiliation Georgetown University Medical Center, Washington, D.C., United States of America

  ⨯
• Catherine Triandafillou,

  Roles Investigation

  Affiliation Biophysical Sciences Graduate Program, University of Chicago, Chicago, Illinois, United States of America

  ⨯
• Joseph E. McCown,

  Roles Investigation

  Affiliation Array BioPharma Inc., Boulder, Colorado, United States of America

  ⨯
• Nam-In Baek,

  Roles Investigation

  Affiliation Graduate School of Biotechnology and Department of Oriental Medicine Biotechnology, Kyung-Hee University, Yongin-si, Gyeonggi-do, Republic of Korea

  ⨯
• Jeong Han Kim,

  Roles Investigation, Validation

  Affiliation Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea

  ⨯
• Young Jae Kim,

  Roles Investigation

  Affiliations Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea

  ⨯
• Celia W. Goulding,

  Roles Resources

  Affiliation Department of Molecular Biology and Biochemistry, University of California, Irvine, California, United States of America

  ⨯
• Charlie E. M. Strauss,

  Roles Conceptualization

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  ⨯
• Jurgen G. Schmidt,

  Roles Conceptualization

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  ⨯
• Gauri S. Shetye,

  Roles Conceptualization

  Affiliation Institute for Tuberculosis Research, College of Pharmacy, University of Illinois, Chicago, Illinois, United States of America

  ⨯
• Sungweon Ryoo,

  Roles Investigation

  Affiliation Clinical Research Centre, Masan National Tuberculosis Hospital, Changwon-si, Gyeongsangnam-do, Republic of Korea

  ⨯
• Eun-Kyeong Jo,

  Roles Supervision

  Affiliations Department of Microbiology, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Department of Medical Science, Chungnam National University School of Medicine, Daejeon, Republic of Korea, Infection Control Convergence Research Center, Chungnam National University School of Medicine, Daejeon, Republic of Korea

  ⨯
• Young Ho Jeon,

  Roles Conceptualization

  Affiliation College of Pharmacy, Korea University, Sejong, Republic of Korea

  ⨯
• Li-Wei Hung,

  Roles Investigation

  Affiliation Physics Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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• Thomas C. Terwilliger,

  Roles Supervision, Writing – review & editing

  Affiliation New Mexico Consortium, Los Alamos, New Mexico, United States of America

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•  [ ... ],
• Chang-Yub Kim

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft

  * E-mail: cykim@lanl.gov

  Current address: MJ Bioefficacy Research Center, Myongji University, Yongin-si, Gyeonggi-do, Republic of Korea

  Affiliation Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

  https://orcid.org/0000-0001-9353-5909

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