Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase

• Verónica Avello,

  Roles Investigation

  Current address: Biotechnology and Biopharmaceutical Laboratory, Pathophysiology Department, School of Biological Sciences, Universidad de Concepción, Concepción, Chile

  Affiliations Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Centro de Biotecnología, Universidad Técnica Federico Santa María, Valparaíso, Chile

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• Mauro Torres,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliations Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom, Department of Chemical Engineering, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, United Kingdom

  https://orcid.org/0000-0002-4054-4323

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• Mauricio Vergara,

  Roles Writing – review & editing

  Affiliation Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

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• Julio Berrios,

  Roles Writing – review & editing

  Affiliation Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile

  https://orcid.org/0000-0002-6180-0023

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• Norma A. Valdez-Cruz,

  Roles Formal analysis, Writing – review & editing

  Affiliation Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México

  https://orcid.org/0000-0002-8581-1173

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• Cristian Acevedo,

  Roles Formal analysis, Methodology, Software, Writing – review & editing

  Affiliations Centro de Biotecnología, Universidad Técnica Federico Santa María, Valparaíso, Chile, Centro Científico Tecnológico de Valparaíso CCTVaL, Universidad Técnica Federico Santa María, Valparaíso, Chile, Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso, Chile

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• Maria Molina Sampayo,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliation Centro de InmunoBiotecnología, Universidad de Chile, Santiago, Chile

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• Alan J. Dickson,

  Roles Writing – review & editing

  Affiliations Manchester Institute of Biotechnology, Faculty of Science and Engineering, University of Manchester, Manchester, United Kingdom, Department of Chemical Engineering, Biochemical and Bioprocess Engineering Group, University of Manchester, Manchester, United Kingdom

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• Claudia Altamirano

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: claudia.altamirano@pucv.cl

  Affiliations Escuela de Ingeniería Bioquímica, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, Centro Regional de Estudio en Alimentos Saludables, R17A10001, Valparaíso, Chile

  https://orcid.org/0000-0003-4448-9074

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