The C4EB study—Transvamix (10% THC / 5% CBD) to treat chronic pain in epidermolysis bullosa: A protocol for an explorative randomized, placebo controlled, and double blind intervention crossover study

• Nicholas H. B. Schräder ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

  * E-mail: n.h.b.schrader@umcg.nl

  Affiliation Department of Dermatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

  https://orcid.org/0000-0002-5131-7097

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• José C. Duipmans,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Department of Dermatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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• Remco J. Renken,

  Roles Conceptualization, Methodology, Software, Writing – review & editing

  Affiliation Cognitive Neuroscience Center, Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, Groningen, The Netherlands

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• Peter Sörös,

  Roles Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliations Department of Neurology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany, Research Center Neurosensory Science, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany

  https://orcid.org/0000-0002-8848-5158

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• Karin M. Vermeulen,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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• Maria C. Bolling ,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  ¶‡ MCB and APW are joint senior authors on this work.

  Affiliation Department of Dermatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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• André P. Wolff

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  ¶‡ MCB and APW are joint senior authors on this work.

  Affiliation Anaesthesiology Pain Centre, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

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