Down-regulation of hepatic expression of GHR/STAT5/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: Crosstalk with Snail-1 and type 2 transforming growth factor-beta receptor

• Mona A. Abu El-Makarem ,

  Roles Conceptualization, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: mona.makarim@yahoo.com

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  https://orcid.org/0000-0001-9202-4373

  ⨯
• Mariana F. Kamel,

  Roles Methodology

  Affiliations Department of Pathology, School of Medicine, Minia University, Minia, Egypt, Department of Pathology, Minia Oncology Center, Minia, Egypt

  ⨯
• Ahmed A. Mohamed,

  Roles Data curation, Supervision

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯
• Hisham A. Ali,

  Roles Data curation, Supervision

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯
• Mahmoud R. Mohamed,

  Roles Data curation, Resources

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯
• Alaa El-Deen M. Mohamed,

  Roles Data curation

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯
• Ahmed M. El-Said,

  Roles Data curation

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯
• Mahmoud G. Ameen,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pathology, South Egypt Cancer Institute, Assuit University, Assuit, Egypt

  ⨯
• Alshymaa A. Hassnine,

  Roles Data curation

  Affiliation Department of Tropical Medicine and Gastroenterology, School of Medicine, Minia University, Minia, Egypt

  https://orcid.org/0000-0003-1352-0948

  ⨯
• Hatem A. Hassan

  Roles Data curation

  Affiliation Department of Internal Medicine, School of Medicine, Minia University, Minia, Egypt

  ⨯