Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells

• Kamilla Stahl-Meyer,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark, Orphazyme A/S, Copenhagen, Denmark

  https://orcid.org/0000-0002-0394-0538

  ⨯
• Mesut Bilgin,

  Roles Data curation, Formal analysis, Methodology, Supervision

  Affiliation Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark

  ⨯
• Lya K. K. Holland,

  Roles Writing – review & editing

  Affiliation Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark

  ⨯
• Jonathan Stahl-Meyer,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark

  ⨯
• Thomas Kirkegaard,

  Roles Conceptualization, Funding acquisition, Resources, Supervision

  Affiliation Orphazyme A/S, Copenhagen, Denmark

  ⨯
• Nikolaj Havnsøe Torp Petersen,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision

  Affiliation Orphazyme A/S, Copenhagen, Denmark

  ⨯
• Kenji Maeda ,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mj@cancer.dk (MJ); kenjim@cancer.dk (KM)

  Affiliation Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark

  ⨯
• Marja Jäättelä

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mj@cancer.dk (MJ); kenjim@cancer.dk (KM)

  Affiliations Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark, Department of Cellular and molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

  https://orcid.org/0000-0001-5950-7111

  ⨯