Annona muricata L. peel extract inhibits carbohydrate metabolizing enzymes and reduces pancreatic β-cells, inflammation, and apoptosis via upregulation of PI3K/AKT genes

• Oluwafemi Adeleke Ojo ,

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: oluwafemiadeleke08@gmail.com

  Current address: Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, Nigeria

  Affiliation Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

  https://orcid.org/0000-0001-9331-396X

  ⨯
• Susan Grant ,

  Contributed equally to this work with: Susan Grant, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

  ⨯
• Jennifer Chidubem Amanze ,

  Contributed equally to this work with: Susan Grant, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

  ⨯
• Abosede Itunuoluwa Oni ,

  Contributed equally to this work with: Susan Grant, Jennifer Chidubem Amanze, Abosede Itunuoluwa Oni

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

  ⨯
• Adebola Busola Ojo,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Ekiti State University, Ado-Ekiti, Nigeria

  ⨯
• Tobiloba Christiana Elebiyo,

  Roles Data curation, Project administration, Software, Validation, Writing – original draft

  Affiliation Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

  ⨯
• Tajudeen Olabisi Obafemi,

  Roles Data curation, Formal analysis, Project administration, Software, Validation, Writing – original draft

  Affiliation Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Nigeria

  ⨯
• Damilare Iyinkristi Ayokunle,

  Roles Project administration, Resources, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pure and Applied Biology, Bowen University, Iwo, Nigeria

  https://orcid.org/0000-0003-1632-3528

  ⨯
• Akingbolabo Daniel Ogunlakin

  Roles Methodology, Project administration, Resources, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Bowen University, Iwo, Nigeria

  ⨯