Riluzole for treating spasticity in patients with chronic traumatic spinal cord injury: Study protocol in the phase ib/iib adaptive multicenter randomized controlled RILUSCI trial

• Maëva Cotinat ,

  Roles Writing – original draft, Writing – review & editing

  * E-mail: maeva.cotinat@ap-hm.fr (MC); frederic.brocard@univ-amu.fr (FB)

  Affiliations Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France, Department of Physical and Rehabilitation Medicine, Sainte Marguerite University Hospital, APHM, Marseille, France

  https://orcid.org/0000-0002-2500-1224

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• Isabelle Boquet,

  Roles Funding acquisition, Methodology, Project administration, Validation, Writing – review & editing

  Affiliation Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France

  https://orcid.org/0000-0002-2028-5846

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• Moreno Ursino,

  Roles Methodology, Validation, Writing – review & editing

  Affiliations Unit of Clinical Epidemiology, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Robert Debré, FCRIN PARTNERS Platform, Université de Paris, Sorbonne Paris-Cité, INSERM U1123 and CIC-EC 1426, Paris, France, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université de Paris, F-75006 Paris, France, Inria, Paris, France

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• Cécile Brocard,

  Roles Conceptualization

  Affiliation Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France

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• Elisabeth Jouve,

  Roles Funding acquisition, Methodology, Validation

  Affiliation Aix Marseille University, APHM, INSERM, Inst Neurosci Syst, UMR1106, Service de Pharmacologie Clinique et Pharmacovigilance, Marseille, France

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• Corinne Alberti,

  Roles Funding acquisition, Methodology, Validation, Writing – review & editing

  Affiliation Unit of Clinical Epidemiology, Assistance Publique-Hôpitaux de Paris, Centre Hospitalier Universitaire Robert Debré, FCRIN PARTNERS Platform, Université de Paris, Sorbonne Paris-Cité, INSERM U1123 and CIC-EC 1426, Paris, France

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• Laurent Bensoussan,

  Roles Funding acquisition, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France, Institut Universitaire de Réadaptation de Valmante Sud, UGECAM, Marseille, France

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• Jean-Michel Viton,

  Roles Funding acquisition, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France, Department of Physical and Rehabilitation Medicine, Sainte Marguerite University Hospital, APHM, Marseille, France

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• Frédéric Brocard ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

  * E-mail: maeva.cotinat@ap-hm.fr (MC); frederic.brocard@univ-amu.fr (FB)

  ¶‡ These senior authors contributed equally to this paper.

  Affiliation Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France

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• Olivier Blin

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Validation, Writing – review & editing

  ¶‡ These senior authors contributed equally to this paper.

  Affiliation Aix Marseille University, APHM, INSERM, Inst Neurosci Syst, UMR1106, Service de Pharmacologie Clinique et Pharmacovigilance, Marseille, France

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