Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infection

• Martha Sedegah,

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

  Affiliation Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America

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• Chad Porter,

  Roles Formal analysis, Writing – review & editing

  Affiliation Translational Clinical Research Department, Naval Medical Research Center, Silver Spring, MD, United States of America

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• Emilie Goguet,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  https://orcid.org/0000-0001-6284-4346

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• Harini Ganeshan,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  ⨯
• Maria Belmonte,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  https://orcid.org/0000-0002-4103-6611

  ⨯
• Jun Huang,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  ⨯
• Arnel Belmonte,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, General Dynamics Information Technology, Falls Church, VA, United States of America

  ⨯
• Sandra Inoue,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, General Dynamics Information Technology, Falls Church, VA, United States of America

  ⨯
• Neda Acheampong,

  Roles Formal analysis, Investigation

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, General Dynamics Information Technology, Falls Church, VA, United States of America

  ⨯
• Allison M. W. Malloy,

  Roles Writing – review & editing

  Affiliation Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

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• Monique Hollis-Perry,

  Roles Investigation, Methodology

  Affiliation Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America

  https://orcid.org/0000-0002-7130-9772

  ⨯
• Belinda Jackson-Thompson,

  Roles Methodology, Project administration

  Affiliations Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  ⨯
• Kathy F. Ramsey,

  Roles Investigation

  Affiliations General Dynamics Information Technology, Falls Church, VA, United States of America, Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America, Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Yolanda Alcorta,

  Roles Investigation

  Affiliations General Dynamics Information Technology, Falls Church, VA, United States of America, Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America

  ⨯
• Santina E. Maiolatesi,

  Roles Methodology

  Affiliations Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America, Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America

  ⨯
• Gregory Wang,

  Roles Investigation

  Affiliations General Dynamics Information Technology, Falls Church, VA, United States of America, Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America

  ⨯
• Anatolio E. Reyes,

  Roles Investigation

  Affiliations General Dynamics Information Technology, Falls Church, VA, United States of America, Clinical Trials Center, Naval Medical Research Center, Silver Spring, MD, United States of America

  ⨯
• Luca Illinik,

  Roles Project administration

  Affiliations Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America, Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Margaret Sanchez-Edwards,

  Roles Project administration

  Affiliations Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America, Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Timothy H. Burgess,

  Roles Funding acquisition, Supervision

  Affiliation Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Christopher C. Broder,

  Roles Conceptualization, Supervision

  Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Eric D. Laing,

  Roles Conceptualization, Methodology, Supervision

  Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Simon D. Pollett,

  Roles Supervision, Writing – review & editing

  Affiliations Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America, Infectious Diseases Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

  ⨯
• Eileen Villasante,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America

  ⨯
• Edward Mitre,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America

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•  [ ... ],
• Michael R. Hollingdale

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mikedc110@gmail.com, Michael.r.hollingdale.ctr@mail.mil

  Affiliations Agile Vaccines and Therapeutics, Naval Medical Research Center, Silver Spring, MD, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States of America

  https://orcid.org/0000-0002-2343-3824

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