Analytical and clinical validation of a custom 15-gene next-generation sequencing panel for the evaluation of circulating tumor DNA mutations in patients with advanced non-small-cell lung cancer

Yock Ping Chow; Norziha Zainul Abidin; Ken Siong Kow; Lye Mun Tho; Chieh Lee Wong

doi:10.1371/journal.pone.0276161

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Open Access

Peer-reviewed

Research Article

Analytical and clinical validation of a custom 15-gene next-generation sequencing panel for the evaluation of circulating tumor DNA mutations in patients with advanced non-small-cell lung cancer

Yock Ping Chow,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliation Clinical Research Centre, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia
⨯
Norziha Zainul Abidin,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation

Affiliation Molecular Diagnostics Laboratory, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia
⨯
Ken Siong Kow,

Roles Investigation, Writing – review & editing

Affiliation Department of Medicine, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia
⨯
Lye Mun Tho,

Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

Affiliation Department of Medicine, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia
⨯
Chieh Lee Wong

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: wongcl@sunmed.com.my

Affiliations Clinical Research Centre, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia, Molecular Diagnostics Laboratory, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia, Department of Medicine, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia, Haematology Unit, Department of Medicine, Sunway Medical Centre, Petaling Jaya, Selangor Darul Ehsan, Malaysia, Centre for Haematology, Hammersmith Hospital, London, United Kingdom, Faculty of Medicine, Imperial College London, London, United Kingdom

https://orcid.org/0000-0003-4919-5825

⨯

Analytical and clinical validation of a custom 15-gene next-generation sequencing panel for the evaluation of circulating tumor DNA mutations in patients with advanced non-small-cell lung cancer

Yock Ping Chow,
Norziha Zainul Abidin,
Ken Siong Kow,
Lye Mun Tho,
Chieh Lee Wong

Published: October 18, 2022
https://doi.org/10.1371/journal.pone.0276161

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Non-small cell lung cancer
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Mutation detection
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Circulating tumor DNA
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Point mutation
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Cancer treatment
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Lung and intrathoracic tumors
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Biopsy
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Next-generation sequencing
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