Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer’s related amyloid-beta pathology

• Shiran Su,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliations National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America

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• Thomas J. Esparza,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America, Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, Maryland, United States of America

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• David L. Brody

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: david.brody@nih.gov, david.brody@usuhs.edu

  Affiliations National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America, Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America, Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-4864-3262

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