Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis

Chunxia Chen; Wan Chen; Xing Zhou; Yaoxuan Li; Xiaorong Pan; Xiaoyu Chen

doi:10.1371/journal.pone.0276083

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Open Access

Peer-reviewed

Research Article

Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis

Chunxia Chen ,

Contributed equally to this work with: Chunxia Chen, Wan Chen, Xing Zhou

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: chunxia251401@126.com (CC); panxrong2015@163.com (XP); 1534746296@qq.com (XC)

Affiliation Department of Pharmacy, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi, P. R. China

https://orcid.org/0000-0003-1950-5909

⨯
Wan Chen ,

Contributed equally to this work with: Chunxia Chen, Wan Chen, Xing Zhou

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Emergency, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi, P. R. China
⨯
Xing Zhou ,

Contributed equally to this work with: Chunxia Chen, Wan Chen, Xing Zhou

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Pharmacy, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi, P. R. China
⨯
Yaoxuan Li,

Roles Formal analysis, Investigation

Affiliation Department of Neurology, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, China
⨯
Xiaorong Pan ,

Roles Conceptualization, Methodology, Writing – review & editing

* E-mail: chunxia251401@126.com (CC); panxrong2015@163.com (XP); 1534746296@qq.com (XC)

Affiliation Department of Hyperbaric Oxygen, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi, P. R. China
⨯
Xiaoyu Chen

Roles Writing – review & editing

* E-mail: chunxia251401@126.com (CC); panxrong2015@163.com (XP); 1534746296@qq.com (XC)

Affiliation Department of Pharmacy, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi, P. R. China
⨯

Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis

Chunxia Chen,
Wan Chen,
Xing Zhou,
Yaoxuan Li,
Xiaorong Pan,
Xiaoyu Chen

Published: November 10, 2022
https://doi.org/10.1371/journal.pone.0276083

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