Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities

Shuhei Agawa; Seiji Futagami; Hiroshi Yamawaki; Rina Tsushima; Kazutoshi Higuchi; Mayu Habiro; Rie Kawawa; Yasuhiro Kodaka; Nobue Ueki; Yoshiyuki Watanabe; Katya Gudis; Rhuji Ohashi; Katsuhiko Iwakiri

doi:10.1371/journal.pone.0275341

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Open Access

Peer-reviewed

Research Article

Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities

Shuhei Agawa,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Seiji Futagami ,

Roles Data curation, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: seiji.futagami@gmail.com

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan

https://orcid.org/0000-0003-0502-8646

⨯
Hiroshi Yamawaki,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Rina Tsushima,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Kazutoshi Higuchi,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Mayu Habiro,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Rie Kawawa,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Yasuhiro Kodaka,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Nobue Ueki,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Yoshiyuki Watanabe,

Roles Data curation

Affiliation Department of Internal Medicine, Kawasaki Rinko General Hospital, Kawasaki, Japan
⨯
Katya Gudis,

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯
Rhuji Ohashi,

Roles Data curation

Affiliation Department of Diagnostic Pathology, Nippon Medical School, Tokyo, Japan
⨯
Katsuhiko Iwakiri

Roles Data curation

Affiliation Department of Gastroenterology, Nippon Medical School, Tokyo, Japan
⨯

Trypsin may be associated with duodenal eosinophils through the expression of PAR2 in early chronic pancreatitis and functional dyspepsia with pancreatic enzyme abnormalities

Shuhei Agawa,
Seiji Futagami,
Hiroshi Yamawaki,
Rina Tsushima,
Kazutoshi Higuchi,
Mayu Habiro,
Rie Kawawa,
Yasuhiro Kodaka,
Nobue Ueki,
Yoshiyuki Watanabe

Published: October 20, 2022
https://doi.org/10.1371/journal.pone.0275341

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Eosinophils
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Serine proteases
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Duodenum
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Cell degranulation
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Tight junctions
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