Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment

Sabine Seeler; Liviu-Ionut Moldovan; Trine Bertelsen; Henrik Hager; Lars Iversen; Claus Johansen; Jørgen Kjems; Lasse Sommer Kristensen

doi:10.1371/journal.pone.0275219

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Open Access

Peer-reviewed

Research Article

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment

Sabine Seeler ,

Contributed equally to this work with: Sabine Seeler, Liviu-Ionut Moldovan

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft

Affiliation Faculty of Health, Department of Biomedicine, Aarhus University, Aarhus, Denmark
⨯
Liviu-Ionut Moldovan ,

Contributed equally to this work with: Sabine Seeler, Liviu-Ionut Moldovan

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Faculty of Health, Department of Biomedicine, Aarhus University, Aarhus, Denmark
⨯
Trine Bertelsen,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark

https://orcid.org/0000-0002-4777-1991

⨯
Henrik Hager,

Roles Investigation, Resources, Writing – review & editing

Affiliation Department of Clinical Pathology, Vejle Hospital, Vejle, Denmark
⨯
Lars Iversen,

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
⨯
Claus Johansen,

Roles Conceptualization, Investigation, Resources, Writing – review & editing

Affiliation Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark
⨯
Jørgen Kjems,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark, Department of Molecular Biology and Genetics (MBG), Aarhus University, Aarhus, Denmark
⨯
Lasse Sommer Kristensen

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

* E-mail: lasse@biomed.au.dk

Affiliation Faculty of Health, Department of Biomedicine, Aarhus University, Aarhus, Denmark

https://orcid.org/0000-0002-5980-7939

⨯

Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment

Sabine Seeler,
Liviu-Ionut Moldovan,
Trine Bertelsen,
Henrik Hager,
Lars Iversen,
Claus Johansen,
Jørgen Kjems,
Lasse Sommer Kristensen

Published: September 29, 2022
https://doi.org/10.1371/journal.pone.0275219

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MicroRNAs
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Psoriasis
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Biopsy
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Gene expression
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Keratinocytes
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