Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels—A pilot study in healthy individuals with implications for COVID-19 and ARDS

• Felix Buder ,

  Contributed equally to this work with: Felix Buder, Simina-Ramona Selejan

  Roles Conceptualization, Software, Writing – original draft, Writing – review & editing

  * E-mail: felix.buder@uks.eu

  Affiliation Department of Internal Medicine III—Cardiology, Angiology and Intensive Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

  https://orcid.org/0000-0001-8634-2324

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• Simina-Ramona Selejan ,

  Contributed equally to this work with: Felix Buder, Simina-Ramona Selejan

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Internal Medicine III—Cardiology, Angiology and Intensive Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

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• Mathias Hohl,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Internal Medicine III—Cardiology, Angiology and Intensive Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

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• Michael Kindermann,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Internal Medicine, Cardiology and Intensive Care Medicine, Caritas Hospital St. Theresia Saarbrücken, Saarbrücken, Germany

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• Christian Herr,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Internal Medicine V–Pulmonology, Allergology and Critical Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

  https://orcid.org/0000-0001-9422-6569

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• Philipp M. Lepper,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Internal Medicine V–Pulmonology, Allergology and Critical Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

  https://orcid.org/0000-0003-3620-0912

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• Robert Bals,

  Roles Data curation, Writing – review & editing

  Affiliations Department of Internal Medicine V–Pulmonology, Allergology and Critical Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus, Saarbrücken, Germany

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• Bernd Salzberger,

  Roles Writing – review & editing

  Affiliation Department for Infection Control and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany

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• Felix Mahfoud,

  Roles Writing – review & editing

  Affiliation Department of Internal Medicine III—Cardiology, Angiology and Intensive Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany

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• Michael Böhm

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Department of Internal Medicine III—Cardiology, Angiology and Intensive Care Medicine, University Hospital, Saarland University, Homburg, Saar, Germany, Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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