Low-dose aspirin to prevent preeclampsia and growth restriction in nulliparous women identified by uterine artery Doppler as at high risk of preeclampsia: A double blinded randomized placebo-controlled trial

• Caroline Diguisto ,

  Roles Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: carolindiguisto@gmail.com

  Affiliations Pôle de Gynécologie Obstétrique, Médecine Fœtale, Médecine et Biologie de la Reproduction, Centre Olympe de Gouges, CHRU de Tours, Tours, France, Université de Tours, Tours, France, Université de Paris, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, INSERM, INRAE,F, Paris, France

  https://orcid.org/0000-0002-1176-0991

  ⨯
• Amelie Le Gouge,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliation INSERM CIC1415, CHRU de Tours, Tours, France

  ⨯
• Marie-Sara Marchand,

  Roles Conceptualization, Supervision, Validation

  Affiliation Service de Pharmacovigilance CHU Tours, Tours, France

  ⨯
• Pascal Megier,

  Roles Investigation, Software, Validation, Writing – review & editing

  Affiliation Department of Gynaecology and Obstetrics, Centre Hospitalier Régional d’Orléans, Orleans, France

  ⨯
• Yves Ville,

  Roles Conceptualization, Data curation, Resources, Supervision

  Affiliations Centre de Dépistage PRIMA FACIE Université de Paris, Paris, France, Maternité, AP-HP, Hôpital Necker, Paris, France

  ⨯
• Georges Haddad,

  Roles Data curation, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Cabinet Mosaïque Santé, La Chaussée Saint Victor, France

  ⨯
• Norbert Winer,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – original draft

  Affiliation Department of Obstetrics and Gynecology, University Hospital of Nantes, Nantes, NUN, INRAE, UMR 1280, PhAN, Université de Nantes, Nantes, France

  https://orcid.org/0000-0001-9897-8493

  ⨯
• Chloé Arthuis,

  Roles Formal analysis, Methodology, Software, Supervision, Validation

  Affiliation Department of Obstetrics and Gynecology, University Hospital of Nantes, Nantes, NUN, INRAE, UMR 1280, PhAN, Université de Nantes, Nantes, France

  ⨯
• Muriel Doret,

  Roles Formal analysis, Methodology, Supervision, Visualization

  Affiliation Service de Gynécologie-Obstétrique, HFME, Hospices Civils de Lyon, Lyon, France

  ⨯
• Veronique Houfflin Debarge,

  Roles Investigation, Project administration, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Obstetrics, CHU Lille, Univ. Lille, ULR 2694—METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, Lille, France

  ⨯
• Anaig Flandrin,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Hôpital Arnaud de Villeneuve, CHRU de Montpellier, Montpellier, France

  ⨯
• Hélène Laurichesse Delmas,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Hôpital d’Estaing, CHU de Clermont-Ferrand, Maternité Clermont Ferrand, Clermont-Ferrand, France

  ⨯
• Denis Gallot,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Hôpital d’Estaing, CHU de Clermont-Ferrand, Maternité Clermont Ferrand, Clermont-Ferrand, France

  ⨯
• Pierre Mares,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Département de Gynécologie Obstétrique, Centre Hospitalo-Universitaire Caremeau, Nîmes, France, École de Maïeutique, Université de Montpellier, Site de Nîmes, Nîmes, France

  ⨯
• Christophe Vayssiere,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Obstetrics and Gynaecology, Paule de Viguier Hospital, Toulouse University Hospital Center, Toulouse, France, Centre for Epidemiology and Population Health Research, Team SPHERE, Toulouse III University, Toulouse, France

  ⨯
• Loïc Sentilhes,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Groupe Hospitalier Pellegrin, CHRU de Bordeaux, Talence, France

  ⨯
• Marie-Therese Cheve,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, CHR Le Mans, Le Mans, France

  ⨯
• Anne Paumier,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Polyclinique de l’Atlantique, Saint-Herblain, France

  ⨯
• Luc Durin,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Polyclinique du Parc, Caen, France

  ⨯
• Bruno Schaub,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Maison de la Femme, de la Mère et de l’Enfant, CHU Martinique, Fort-de-France, Martinique, France

  ⨯
• Veronique Equy,

  Roles Investigation, Writing – original draft, Writing – review & editing

  Affiliation Service de Gynécologie-Obstétrique, Hôpital Couple Enfant, CHRU de Grenoble, La Tronche, France

  ⨯
• Bruno Giraudeau,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Université de Tours, Tours, France, INSERM CIC1415, CHRU de Tours, Tours, France

  ⨯
• Franck Perrotin,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision

  Affiliations Pôle de Gynécologie Obstétrique, Médecine Fœtale, Médecine et Biologie de la Reproduction, Centre Olympe de Gouges, CHRU de Tours, Tours, France, Université de Tours, Tours, France

  ⨯
•  [ ... ],
• for the Groupe de Recherche en Obstétrique et Gynécologie (GROG)

  ¶Membership of the Groupe de Recherche en Obstétrique et Gynécologie (GROG) is provided in the Acknowledgments.

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