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Open Access
Peer-reviewed
Research Article
First-in-human study to evaluate safety, tolerability, and immunogenicity of heterologous regimens using the multivalent filovirus vaccines Ad26.Filo and MVA-BN-Filo administered in different sequences and schedules: A randomized, controlled study
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Viki Bockstal ,
Contributed equally to this work with: Viki Bockstal, Georgi Shukarev, Chelsea McLean
Roles Data curation, Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing
Current address: ExeVir, Ghent, Belgium
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Georgi Shukarev ,
Contributed equally to this work with: Viki Bockstal, Georgi Shukarev, Chelsea McLean
Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Chelsea McLean ,
Contributed equally to this work with: Viki Bockstal, Georgi Shukarev, Chelsea McLean
Roles Data curation, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: cmclean@its.jnj.com
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Neil Goldstein,
Roles Formal analysis, Writing – original draft, Writing – review & editing
Current address: Private Consultant, Formerly of Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Stephan Bart,
Roles Investigation, Writing – review & editing
Affiliation Optimal Research, LLC, Rockville, Maryland, United States of America
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Auguste Gaddah,
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Beerse, Belgium
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Dickson Anumenden,
Roles Formal analysis, Methodology, Writing – review & editing
Current address: Parexel, Wavre, Belgium
Affiliation Janssen Infectious Diseases and Vaccines, Beerse, Belgium
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Jeroen N. Stoop,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Anne Marit de Groot,
Roles Investigation, Methodology, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Maria G. Pau,
Roles Conceptualization, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Jenny Hendriks,
Roles Formal analysis, Visualization, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Stephen C. De Rosa,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Kristen W. Cohen,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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M. Juliana McElrath,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Benoit Callendret,
Roles Conceptualization, Funding acquisition, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Kerstin Luhn,
Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Macaya Douoguih,
Roles Conceptualization, Supervision, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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Cynthia Robinson
Roles Formal analysis, Methodology, Writing – review & editing
Affiliation Janssen Infectious Diseases and Vaccines, Leiden, The Netherlands
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First-in-human study to evaluate safety, tolerability, and immunogenicity of heterologous regimens using the multivalent filovirus vaccines Ad26.Filo and MVA-BN-Filo administered in different sequences and schedules: A randomized, controlled study
- Viki Bockstal,
- Georgi Shukarev,
- Chelsea McLean,
- Neil Goldstein,
- Stephan Bart,
- Auguste Gaddah,
- Dickson Anumenden,
- Jeroen N. Stoop,
- Anne Marit de Groot,
- Maria G. Pau
- Published: October 5, 2022
- https://doi.org/10.1371/journal.pone.0274906