Engineered peptide PLG0206 overcomes limitations of a challenging antimicrobial drug class

• David B. Huang ,

  Contributed equally to this work with: David B. Huang, Kimberly M. Brothers

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: david.huang@peptilogics.com (DBH); ken.urish@pitt.edu (KLU)

  Affiliation Peptilogics, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0002-8342-3193

  ⨯
• Kimberly M. Brothers ,

  Contributed equally to this work with: David B. Huang, Kimberly M. Brothers

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  https://orcid.org/0000-0003-2055-9760

  ⨯
• Jonathan B. Mandell,

  Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Masashi Taguchi,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliations Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Orthopedic Surgery, Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan

  ⨯
• Peter G. Alexander,

  Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Dana M. Parker,

  Roles Data curation, Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Dean Shinabarger,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Micromyx, Kalamazoo, Michigan, United States of America

  ⨯
• Chris Pillar,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Micromyx, Kalamazoo, Michigan, United States of America

  ⨯
• Ian Morrissey,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation IHMA, Monthey, Switzerland

  ⨯
• Stephen Hawser,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation IHMA, Monthey, Switzerland

  ⨯
• Parviz Ghahramani,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Inncelerex, Jersey City, New Jersey, United States of America

  ⨯
• Despina Dobbins,

  Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Peptilogics, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Nicholas Pachuda,

  Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Peptilogics, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Ronald Montelaro,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

  ⨯
• Jonathan D. Steckbeck,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Writing – review & editing

  Affiliation Peptilogics, Pittsburgh, Pennsylvania, United States of America

  ⨯
•  [ ... ],
• Kenneth L. Urish

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: david.huang@peptilogics.com (DBH); ken.urish@pitt.edu (KLU)

  Affiliations Department of Orthopedic Surgery, Arthritis and Arthroplasty Design Group, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, The Bone and Joint Center, Magee Women’s Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Department of Bioengineering, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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