IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models

Jose E. Heredia; Clara Sorenson; Sean Flanagan; Victor Nunez; Charles Jones; Angela Martzall; Laurie Leong; Andres Paler Martinez; Alexis Scherl; Hans D. Brightbill; Nico Ghilardi; Ning Ding

doi:10.1371/journal.pone.0274582

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Open Access

Peer-reviewed

Research Article

IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models

Jose E. Heredia,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Discovery Immunology, Genentech, South San Francisco, CA, United States of America
⨯
Clara Sorenson,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Sean Flanagan,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Victor Nunez,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Charles Jones,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Angela Martzall,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Laurie Leong,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America
⨯
Andres Paler Martinez,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Discovery Immunology, Genentech, South San Francisco, CA, United States of America
⨯
Alexis Scherl,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Pathology, Genentech, South San Francisco, CA, United States of America

https://orcid.org/0000-0001-6130-3118

⨯
Hans D. Brightbill,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Department of Translational Immunology, Genentech, South San Francisco, CA, United States of America
⨯
Nico Ghilardi,

Roles Project administration, Resources, Supervision, Visualization

Current address: Dice Therapeutics, South San Francisco, CA, United States of America

Affiliation Department of Discovery Immunology, Genentech, South San Francisco, CA, United States of America
⨯
Ning Ding

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ding.ning@gene.com

Affiliation Department of Discovery Immunology, Genentech, South San Francisco, CA, United States of America

https://orcid.org/0000-0001-6560-2967

⨯

IL-23 signaling is not an important driver of liver inflammation and fibrosis in murine non-alcoholic steatohepatitis models

Jose E. Heredia,
Clara Sorenson,
Sean Flanagan,
Victor Nunez,
Charles Jones,
Angela Martzall,
Laurie Leong,
Andres Paler Martinez,
Alexis Scherl,
Hans D. Brightbill

Published: September 15, 2022
https://doi.org/10.1371/journal.pone.0274582

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