Cell death induced in glioblastoma cells by Plasma-Activated-Liquids (PAL) is primarily mediated by membrane lipid peroxidation and not ROS influx

Sebnem Gunes; Zhonglei He; Evanthia Tsoukou; Sing Wei Ng; Daniela Boehm; Beatriz Pinheiro Lopes; Paula Bourke; Renee Malone; Patrick J. Cullen; Wenxin Wang; James Curtin

doi:10.1371/journal.pone.0274524

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Peer-reviewed

Research Article

Cell death induced in glioblastoma cells by Plasma-Activated-Liquids (PAL) is primarily mediated by membrane lipid peroxidation and not ROS influx

Sebnem Gunes ,

Contributed equally to this work with: Sebnem Gunes, Zhonglei He

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: james.curtin@tudublin.ie (JC); sebnem.gunes@tudublin.ie (SG)

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland
⨯
Zhonglei He ,

Contributed equally to this work with: Sebnem Gunes, Zhonglei He

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, Ireland
⨯
Evanthia Tsoukou,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland
⨯
Sing Wei Ng,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliations Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland, Plasma Research Group, School of Biosystems and Food Engineering, University College Dublin, Belfield, D4, Dublin, Ireland
⨯
Daniela Boehm,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland
⨯
Beatriz Pinheiro Lopes,

Roles Conceptualization, Writing – review & editing

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland
⨯
Paula Bourke,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliations Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland, Plasma Research Group, School of Biosystems and Food Engineering, University College Dublin, Belfield, D4, Dublin, Ireland
⨯
Renee Malone,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland
⨯
Patrick J. Cullen,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, Australia
⨯
Wenxin Wang,

Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

Affiliation Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin, Ireland
⨯
James Curtin

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: james.curtin@tudublin.ie (JC); sebnem.gunes@tudublin.ie (SG)

Affiliations BioPlasma Research Group, School of Food Science and Environmental Health, Technological University Dublin, Dublin, Ireland, Environmental Sustainability & Health Institute (ESHI), Technological University Dublin, Dublin, Ireland, Faculty of Engineering and Built Environment, Technological University Dublin, Dublin, Ireland

https://orcid.org/0000-0002-9320-9254

⨯

Cell death induced in glioblastoma cells by Plasma-Activated-Liquids (PAL) is primarily mediated by membrane lipid peroxidation and not ROS influx

Sebnem Gunes,
Zhonglei He,
Evanthia Tsoukou,
Sing Wei Ng,
Daniela Boehm,
Beatriz Pinheiro Lopes,
Paula Bourke,
Renee Malone,
Patrick J. Cullen,
Wenxin Wang

Published: September 22, 2022
https://doi.org/10.1371/journal.pone.0274524

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