Patient-derived monoclonal antibody neutralizes HCV infection in vitro and vivo without generating escape mutants

• Hiroshi Yokokawa ,

  Contributed equally to this work with: Hiroshi Yokokawa, Midori Shinohara, Noriko Nakamura

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hiro_ykkw@msn.com (HY); wakita@nih.go.jp (TW)

  Affiliations Pharmaceutical Research Laboratory, Toray Industries, Inc., Kanagawa, Japan, Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  https://orcid.org/0000-0002-3384-7043

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• Midori Shinohara ,

  Contributed equally to this work with: Hiroshi Yokokawa, Midori Shinohara, Noriko Nakamura

  Roles Formal analysis, Investigation, Methodology

  Affiliation Medical & Biological Laboratories Co., Ltd., Tokyo, Japan

  ⨯
• Yuji Teraoka ,

  Roles Data curation, Formal analysis, Investigation, Methodology

  ¶‡ YT and MI also contributed equally to this work.

  Affiliations Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan

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• Michio Imamura ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources

  ¶‡ YT and MI also contributed equally to this work.

  Affiliations Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan

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• Noriko Nakamura ,

  Contributed equally to this work with: Hiroshi Yokokawa, Midori Shinohara, Noriko Nakamura

  Roles Data curation, Funding acquisition, Investigation, Visualization

  Affiliation Pharmaceutical Research Laboratory, Toray Industries, Inc., Kanagawa, Japan

  ⨯
• Noriyuki Watanabe,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Tomoko Date,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Hideki Aizaki,

  Roles Funding acquisition, Project administration, Resources

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

  ⨯
• Tomokatsu Iwamura,

  Roles Conceptualization, Methodology, Resources

  Affiliation Pharmaceutical Research Laboratory, Toray Industries, Inc., Kanagawa, Japan

  ⨯
• Hideki Narumi,

  Roles Data curation, Funding acquisition, Resources, Supervision

  Affiliation Pharmaceutical Research Laboratory, Toray Industries, Inc., Kanagawa, Japan

  ⨯
• Kazuaki Chayama,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision

  Affiliations Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan, Collaborative Research Laboratory of Medical Innovation, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

  https://orcid.org/0000-0002-5530-5341

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• Takaji Wakita

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: hiro_ykkw@msn.com (HY); wakita@nih.go.jp (TW)

  Affiliation Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan

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