New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies

• Ahmed A. Gaber,

  Roles Methodology

  Affiliation Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Mohamed Sobhy,

  Roles Methodology

  Affiliation Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Abdallah Turky,

  Roles Methodology

  Affiliation Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Wagdy M. Eldehna,

  Roles Conceptualization, Formal analysis, Resources

  Affiliation Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

  https://orcid.org/0000-0001-6996-4017

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• Samiha A. El-Sebaey,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

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• Souad A. El-Metwally,

  Roles Methodology

  Affiliation Department of Basic Science, Higher Technological institute, 10th of Ramadan City, Egypt

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• Abeer M. El-Naggar,

  Roles Investigation, Methodology

  Affiliation Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, Cairo, Egypt

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• Ibrahim M. Ibrahim,

  Roles Methodology

  Affiliation Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt

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• Eslam B. Elkaeed,

  Roles Funding acquisition

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Riyadh, Saudi Arabia

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• Ahmed M. Metwaly,

  Roles Project administration, Writing – review & editing

  Affiliations Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt, Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

  https://orcid.org/0000-0001-8566-1980

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• Ibrahim H. Eissa

  Roles Supervision, Validation, Writing – review & editing

  * E-mail: Ibrahimeissa@azhar.edu.eg

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0002-6955-2263

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