A distinct four-value blood signature of pyrexia under combination therapy of malignant melanoma with dabrafenib and trametinib evidenced by an algorithm-defined pyrexia score

• Hannah Schaefer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Dermatology, RWTH Aachen University Hospital, Aachen, Germany

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• Albert Rübben ,

  Roles Conceptualization, Formal analysis, Methodology, Software, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: albert.ruebben@post.rwth-aachen.de

  Affiliations Department of Dermatology, RWTH Aachen University Hospital, Aachen, Germany, Department of Dermatology, St. Nikolaus Hospital, Eupen, Belgium, Center for Integrated Oncology, CIO ABCD, Aachen, Bonn, Cologne, Düsseldorf, Germany

  https://orcid.org/0000-0002-2704-4754

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• André Esser,

  Roles Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Department of Occupational, Social and Environmental Medicine, RWTH Aachen University Hospital, Aachen, Germany

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• Arturo Araujo,

  Roles Software, Writing – review & editing

  Affiliation Department of Media, Culture and Language, University of Roehampton, London, United Kingdom

  https://orcid.org/0000-0002-0269-2819

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• Oana-Diana Persa,

  Roles Investigation, Writing – review & editing

  Current address: Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany

  Affiliations Center for Integrated Oncology, CIO ABCD, Aachen, Bonn, Cologne, Düsseldorf, Germany, Department of Dermatology and Venereology, University Hospital Cologne, University of Cologne, Cologne, Germany

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• Marike Leijs

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Department of Dermatology, RWTH Aachen University Hospital, Aachen, Germany, Department of Dermatology, St. Nikolaus Hospital, Eupen, Belgium, Center for Integrated Oncology, CIO ABCD, Aachen, Bonn, Cologne, Düsseldorf, Germany

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