Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology

Nikhil Mayor; Harry Knights; Aleksandra Kotwica; Andrew Solomon Joseph Coppola; Harriet Hunter; Nathan Jeffreys; Alexander Morgan; Shivani Gupta; James Prentice; Rebecca Macfarlane; Emma Russell-Jones; Theodore Dassios; David Russell-Jones

doi:10.1371/journal.pone.0273402

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Open Access

Peer-reviewed

Research Article

Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology

Nikhil Mayor ,

Contributed equally to this work with: Nikhil Mayor, Harry Knights, Aleksandra Kotwica

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: nikmayor@googlemail.com

Affiliation Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom

https://orcid.org/0000-0003-2681-2501

⨯
Harry Knights ,

Contributed equally to this work with: Nikhil Mayor, Harry Knights, Aleksandra Kotwica

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom, University College London, London, United Kingdom

https://orcid.org/0000-0002-8184-7208

⨯
Aleksandra Kotwica ,

Contributed equally to this work with: Nikhil Mayor, Harry Knights, Aleksandra Kotwica

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, United Kingdom
⨯
Andrew Solomon Joseph Coppola,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Harriet Hunter,

Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom
⨯
Nathan Jeffreys,

Roles Data curation, Methodology, Project administration, Writing – review & editing

Affiliation Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom
⨯
Alexander Morgan,

Roles Data curation, Investigation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom
⨯
Shivani Gupta,

Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom
⨯
James Prentice,

Roles Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom
⨯
Rebecca Macfarlane,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

Affiliation Epsom & St Helier NHS Foundation Trust, Epsom, United Kingdom
⨯
Emma Russell-Jones,

Roles Conceptualization, Investigation, Project administration, Supervision, Validation, Writing – review & editing

Affiliation King’s College London, London, United Kingdom
⨯
Theodore Dassios ,

Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

¶‡ These authors are joint last authors on this work. TD and DR-J also contributed equally to this work

Affiliation King’s College London, London, United Kingdom
⨯
David Russell-Jones

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

¶‡ These authors are joint last authors on this work. TD and DR-J also contributed equally to this work

Affiliations Royal Surrey NHS Foundation Trust, Guildford, Surrey, United Kingdom, University of Surrey, Guildford, United Kingdom
⨯

Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology

Nikhil Mayor,
Harry Knights,
Aleksandra Kotwica,
Andrew Solomon Joseph Coppola,
Harriet Hunter,
Nathan Jeffreys,
Alexander Morgan,
Shivani Gupta,
James Prentice,
Rebecca Macfarlane

Published: October 20, 2022
https://doi.org/10.1371/journal.pone.0273402

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